NFL : Chicago Bears vs San Francisco 49ers Odds & Prediction

Game Info: December 28, 2025 8:20PM EST @ Levi’s Stadium

The Chicago Bears are heading to Levi’s Stadium to face off with the San Francisco 49ers in a match-up of teams with opposite recent form. The Bears have managed to win four out of the last five games but, on the other hand, the 49ers have not lost any of their last five games and are supported by a powerful offense and defense, which makes the situation even more interesting for the spectators.

Betting Odds and Info

These are the latest odds as of writing:

Moneyline: Bears 2.62 , 49ers 1.51

Spread: Bears +3 , 49ers -3

Over/Under: 52.5

Team Recent Performance

Chicago Bears

The Bears have managed to win four games from their last five, among them two important wins over Cleveland and Philadelphia. Throughout this stretch, they have an ATS record of 3-2, with only two games out of five getting over the total points – a sign of a team that is tough in winning and good at controlling the scoring.

San Francisco 49ers

The 49ers have been victorious in their last five matches and have been commandingly dominant in both the offensive and defensive aspects. They have also been successful in each of the encounters by the betting line, while totals have been exceeded in three out of five games, illustrating a harmonious, scoring team of sorts.

Team Head-to-Head Matchup

Bears (1-2) and 49ers (2-1) might be playing a game with different offensive outputs. Chicago scores on average 18 points and has a run in total of 230 yards per match, on the contrary, San Francisco scores with an average of 27 points and has 416.7 total yards. The 49ers are on top of both setups, the passing, and the running, but all the teams are turning the ball over once on average per game laying the ground for an intriguing encounter.

Betting Trends

Chicago Bears

Lately, the Bears have been a powerful factor against the spread (ATS), winning five of their last six games and winning five out of seven during road games, but they have a hard time beating their historical opponent, the 49ers, 7-13 ATS overall and 2-9 while visiting. Recent matchups have stayed UNDER the totals most of the time, but matchups between the NFC West teams have usually gone OVER. The Bears in December have only two wins and five losses SU, which is a sign of inconsistency during the end of the season.

San Francisco 49ers

In their last five games, the 49ers have won 5 times and not lost any times – this goes for both Over/Under as well, and they are a strong home team with a record of 9-2 ATS vs. the Bears. The trend of putting up more points than is set by the line has been a dominant one lately, it includes four out of the last six matches against Chicago and five out of six games in December.

SPORTBOOK.AG’s Prediction

The 49ers will win and cover the spread with the total going over 52.5.

Check out our suggested sportbook listed if you’re seeking for a good site to wager on this matchup.