NFL: Seattle Seahawks at Arizona Cardinals Odds & Prediction

Game Info: Friday, September 26, 2025, 8:15 PM ET, State Farm Stadium, Glendale, AZ

Betting Odds

As of the latest lines, the Arizona Cardinals are slight favorites at home:

Spread: Cardinals -1.5, Seahawks +1.5

Moneyline: Cardinals -140, Seahawks +120

Total (Over/Under): 43.5 points

Seahawks Betting Preview

Seattle is coming into this game riding high after a solid victory over the Saints, putting up 38 points in the first half. Yeah, you heard that right, the first half. Sam Darnold had a good game, and while he’s not exactly at Mahomes’ level just yet, he’s managing the offense well and giving the playmakers a chance to show off.

The biggest problem is the defense. With Devon Witherspoon and Julian Love both injured, the Seahawks are short on depth in the secondary, which isn’t ideal when up against a team that likes to spread the field. On the bright side, Seattle’s offense ranks in the top five for EPA/play after three weeks, and if they keep this up, they’ll be a tough matchup in this game.

Cardinals Betting Preview

Arizona recently suffered a narrow 16-15 defeat to San Francisco, a match they nearly won at the last moment but just couldn’t finish. Their defense has been solid, ranking eighth in DVOA, but that number feels a bit inflated given the opponents they’ve played. With James Conner out, the running game is struggling without him. This puts more pressure on the passing game, which has been inconsistent at best.

The Cardinals are playing at home, which really changes the game especially during a short week. Still, this matchup will mainly depend on how well they can pressure Darnold and force him to make mistakes. If they can’t pull that off, it’s hard to see how they’ll keep up in the game.

Matchup/League Facts

The Cardinals have a 54.3% chance of winning the game, according to a predictive model based on current odds. 

The over/under is set at 43.5 points.

The spread for this matchup is Cardinals -1.5 and Seahawks +1.5, making it one of the tightest spreads in Week 4.

Seahawks at Cardinals Prediction

This Seahawks vs. Cardinals game is your classic Thursday night puzzle. Even though simulations hint that Arizona might have a tiny edge, I’m leaning towards Seattle, mostly due to their powerful offense and the reality that Arizona’s injuries and issues with closing out games are pretty hard to overlook. If Darnold can hold onto the ball and the Seahawks can pull off some crucial stops, they should take the win.

Sportbook.AG Final Prediction: Pick: Seahawks +1.5 | Prediction: Seahawks 20, Cardinals 17