NFL: Washington Commanders at Green Bay Packers Odds & Predictions

Game Info: Friday, September 12, 2025, 8:15 pm E.T. Lambeau Field, Green Bay, WI

Betting Odds

Spread: Packers -3.5 (-110), Commanders +3.5 (-110)

Moneyline: Packers -187, Commanders +156

Total (O/U): 48.5 points (Over -110 / Under -110)

Green Bay is coming into the game as a small favorite, but savvy bettors are looking at Washington’s potential as a road underdog.

Commanders Betting Preview

Washington is coming into this game after a tough 21–6 victory against the Giants, where Jayden Daniels showed both poise and skill in his first NFL game. Although the rookie’s numbers weren’t all that remarkable, he managed to steer clear of turnovers and displayed some thrilling dual-threat potential. Still, the most impressive part was the Commanders’ defense, they restricted New York to only 3.9 yards per play and controlled the line of scrimmage.

From a betting perspective, Washington has been a reliable road underdog since last season, successfully covering the spread in five of their last seven away games. Their strong front seven fits well with Green Bay’s zone running approach, and if Daniels can make some plays on the run, Washington could stay in the game or even pull off a surprise win.

Packers Betting Preview

Green Bay kicked off their season with a solid win against Detroit, taking the game 27–13, largely due to Jordan Love’s stellar performance, where he passed for 238 yards and two touchdowns. The Packers’ defense really shone as well, managing to sack Jared Goff four times and causing two turnovers. Under Matt LaFleur at home, Green Bay has been outstanding, they’ve managed to cover the spread in 11 out of their last 14 games at Lambeau.

This game definitely favors Green Bay because of their experience and stability. Love is entering his third year as a starter and appears to be becoming more comfortable directing the offense. If the Packers can establish the run game early and keep Daniels contained in the pocket, they’ll have the advantage.

Matchup/League Facts

Commanders are 5-2 ATS in their last seven road games.

Packers have a strong ATS record at home under Matt LaFleur, potentially covering in a high percentage of recent home games.

Washington’s defense had a high pressure rate in Week 1.

This matchup features a top-10 scoring defense from 2024 in Green Bay. 

Commanders at Packers Prediction

This game between the Commanders and the Packers is a classic early-season challenge. Washington is youthful, fast, and resilient but playing at Lambeau under the lights is a completely different story. Expect a tight, low-scoring match where turnovers and field position will be key. I believe the Commanders will manage to cover the spread, but Green Bay’s experience should give them the edge for a narrow win.

Sportbook.AG Final Prediction: Packers 23, Commanders 20 Best Bet: Commanders +3.5 Lean: Under 48.5

This game has all the elements for a true nail-biter, and if you’re betting on it, don’t be surprised if it all comes down to a last-minute drive in the fourth quarter.