NFL : San Francisco 49ers vs Seattle Seahawks Odds & Prediction

Game Info: January 17, 2026 8:00PM EST @ Lumen Field

The San Francisco 49ers are making their way to Lumen Field to face the Seattle Seahawks in a battle that is creating a lot of excitement among the bettors. The duel between the two sides is sure to be full of suspense and will be characterized by the teams’ good play and recent trends indicating low-turnover situations.

Betting Odds and Info

These are the latest odds as of writing:

Moneyline: 49ers 3.78 , Seahawks 1.28

Spread: 49ers +7.5 , Seahawks -7.5

Over/Under: 45.5

Team Recent Performance

San Francisco 49ers

The San Francisco 49ers have emerged victorious in four out of their five latest games, highlighting their potent offense through several high-scoring games, and not being able to pull off a few tight games, including those against Seattle and Chicago.

Seattle Seahawks

They are on a roll and have won five in a row. They not only secured wins but also covered the spread during most of the games, including great victories both away and at home, although they narrowly lost in close games with the Rams and Colts. The scoring fluctuated with some games going OVER while others remained UNDER reflecting a combination of explosive offensive plays and good defensive efforts.

Team Head-to-Head Matchup

In their latest matches, the Seattle Seahawks and the San Francisco 49ers were fighting like equals. The San Francisco team has won 1 and lost 2 games while the Seattle guys have done the opposite, winning 2 and losing 1, while in all of these matches both teams have scored under the line set for them. On the offensive side, Seattle is slightly above with an average of 15.3 points and 293 total yards per game in comparison with San Francisco’s 12.3 points and 278 yards. The rushing game goes to Seattle (119 vs. 101 yards) and passing groups are almost equal. It’s going to be hard to choose the winner as both teams keep their turnovers low.

Betting Trends

San Francisco 49ers

The 49ers have been on fire, winning 7 and losing only 1 both SU and ATS in their last eight matches. Besides that, they’ve really overwhelmed the Seahawks in a recent past, having a record of 7-2 SU and 6-3 ATS. When it comes to road games, San Francisco has a remarkable record of 5-0 ATS in its last five games and 4-1 ATS against Seattle away from home. The total points scored in their matches are usually low, and so it has been with their last seven Saturday games with the result finishing UNDER five times.

Seattle Seahawks

The Seahawks are definitely in the winning mood lately, recording 7-0 SU in their last seven matches and 12-4 ATS in their last 16. At their home ground, they are unbeaten at 5-0 SU but have managed to win only once against the 49ers for 4 ATS. They have been dominating the West division in NFC, having won all 5 games SU and lost only once ATS. Point spread numbers show no clear pattern as the games have been a mixture with some going UNDER against the 49ers while many recent Saturday games have been OVER.

SPORTBOOK.AG’s Prediction

The Seahawks will win and cover the spread with the total staying 45.5.

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