NFL : San Francisco 49ers vs Buffalo Bills Odds & Prediction

Game Info: December 1, 2024 8:20PM EST @ Highmark Stadium

The 49ers hope to bounce back after many tough games, while the Bills ride the momentum of several wins in a row. They compete against each other with completely different strengths. San Francisco has its strength with an evenly distributed offense while Buffalo exhibits a consistent playing level for both offenses and defenses. Prime time is always reserved for this clash at Highmark Stadium, where both teams strive to have a shot at playoffs fortified by their respective wins.

Betting Odds and Info

These are the latest odds as of writing:

Moneyline: 49ers 3.49 , Bills 1.32

Spread: 49ers +6 , Bills -6

Over/Under: 44

Team Recent Performance

San Francisco 49ers

On November 25, they took it from the Green Bay side with a blowout score of 10-38 as 6.5 points underdogs, not able to cover an over bet (44.5). One week before, they fell short at the Seattle front 17-20 with 6 points in their favor, thus also failing to cover and stayed under (48.5). On November 11, they narrowly beat Tampa Bay 23-20, failing to meet a spread of 6.5 points and staying under (50.5). The only win happened on October 28 with a score of 30-24 over the Dallas team as they took a -5.5 point spread, covering and topping the over (47.5). However, they couldn’t boil down on October 21 when playing against Kansas City while holding a 2.5-point favoritism, but with a score of 18-28. They maintained covering with a stay under (48).

Buffalo Bills

Their run of five strong consecutive wins begins with a 30-21 victory on November 18 against Kansas City while being favored by 2.5 points, which covered the spread and hit the total at 47. On November 11, they faced Indianapolis and emerged victorious 30-20 while being favored by 4.5 points, again covering and going over (46.5). Their last matchup remained at 30-27 in favor of them over Miami on November 4, and there was a failure to cover the spread of 6.5 with a scoring over the total at 49. On October 28, they outscored Seattle 31-10 as 3-point favorites, bringing that in and under on the 45.5 total. Just to round it off, on October 21, they pummeled the Tennessee Titans 34-10 as 9.5-point favorites, covering the spread with the game going over (41).

Team Head-to-Head Matchup

At present, both teams hold identical records at 4-4, although Buffalo is ahead in betting performance, having recorded a 5-3 against the spread as opposed to 3-5 for San Francisco. Both franchises have identical records in the Over/Under of five wins against three losses. Offensively, San Francisco scores an average of 23.12 points a game, just ahead of Buffalo’s 21.12 average. Rushing stats are almost lumped together. Also, San Francisco does 135.88 yards, whereas Buffalo covers 136.50 in the rushing department. Buffalo passes the ball slightly more often than San Francisco per game-three passes: 34.50 to 30.62. Completion percentage is a little higher, however, for San Francisco-61.63% to 60.87%. The Net Passing Yards for these two teams are 216.12 against the citizens of California’s 207.62. Thus, they have only a small edge in total yards (352 against San Francisco’s 344.12). Turnovers are generally in favor of San Francisco, which averages 1.75 on defense compared to Buffalo’s 2.12.

Team Injuries

San Francisco 49ers

Trent Williams (T, ankle), Nick Bosa (DE, hip), and Deommodore Lenoir (CB, knee) are absent. Season-ending injuries were suffered by Javon Hargrave (NT, triceps), Brandon Aiyuk (WR, ACL), and Curtis Robinson (LB, ACL), whereas Tashaun Gipson Sr. (S, suspended) is indefinitely out. Brock Purdy (QB, shoulder), Charvarius Ward (CB, personal), Kevin Givens (DT, groin), and Jacob Cowing (WR, concussion) changed their statuses to probable. Other considerable names include Chris Conley (WR, knee) and Demetrius Flannigan-Fowles (LB, knee) who are still doubtful. Other notable absentees include Mitch Wishnowsky (P, back), Ambry Thomas (CB, undisclosed), Talanoa Hufanga (S, wrist), and Eli Mitchell (RB, hamstring), who are all on the IR list.

Buffalo Bills

Probable for Matt Milano (LB, biceps) and Spencer Brown (T, ankle), out for Dalton Kincaid (TE, knee). DeWayne Carter (DT, wrist) and Keon Coleman (WR, wrist) are listed as questionable. Dawuane Smoot (DE, wrist), Shane Buechele (QB, neck), Travis Clayton (T, shoulder), and Tylan Grable (T, groin) remain on IR.

SPORTBOOK.AG’s Prediction

The Buffalo Bills will win and cover the spread with the total staying under 44.

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