NFL: Los Angeles Chargers at Las Vegas Raiders Odds & Prediction

Game Info: Tuesday, September 16, 2025, 10:00 PM ET, Allegiant Stadium, Las Vegas, NV

Betting Odds

Right now, the Chargers are the favorites by -3.5 on the road, with a total set at 46.5. The moneyline odds show Chargers at -185 and Raiders at +154, indicating about a 65% likelihood of a win for L.A. The sportsbooks are getting equal action on both teams, but early sharp bets have leaned towards the Bolts.

Chargers Betting Preview

The Chargers really showed their stuff in Week 1, taking down the Chiefs 27-21 in São Paulo. Justin Herbert was on fire, passing for 318 yards, 3 touchdowns, and no interceptions. What stood out wasn’t just the stats, but the chemistry he’s building with his young receivers. Quentin Johnston and Ladd McConkey are emerging as serious threats alongside Keenan Allen, giving Herbert a deep and flexible range of options.

This squad is built to secure games with solid defense. With Derwin James, Khalil Mack, and Tuli Tuipulotu at the forefront, they ranked in the top five for EPA/play last season. They play hard, fast, and hardly ever miss tackles. From a betting angle, the Chargers were phenomenal last year—ending with a 13-4 record against the spread, and a flawless 5-0 when favored by 3.5 points or more. This team doesn’t just win—they also cover the spread.

Raiders Betting Preview

The Raiders started the Pete Carroll era with a hard-fought 20-13 win over New England. Geno Smith threw for 362 yards and looked surprisingly comfortable in Carroll’s system. Rookie Brock Bowers displayed his amazing athleticism, accumulating 103 yards before he slightly injured his knee towards the end of the game.

But let’s face it. the Patriots are not the Chargers. Vegas had a tough time last season when they were the underdogs, finishing 2-12 straight up, and only 1-9 when they were at +150 or more. Their defense did well last week, but this game will really challenge them. If they can’t put pressure on Herbert, he’ll tear them apart.

Matchup/League Facts

The Chargers have won 3 of the last 5 games in this rivalry, but the Raiders have outscored them overall, 137-121 during that stretch.

Last season, L.A. showcased a strong defense, permitting just 17.7 points per game, the best in the NFL.

Vegas had a tough time on defense, allowing 25 or more points in 11 games last year, including 4 against their divisional foes.

In the last 10 matchups between the Chargers and Raiders, the total score has gone under 7 times.

Chargers at Raiders Prediction

This game between the Chargers and Raiders looks like one where the better team will likely win and cover the spread. Herbert is locked in, the defense is solid, and they’ve usually done well against Vegas in these situations. The Raiders are improving, but they’re still not really ready to take a game like this.

Sportbook.AG Final Prediction: Chargers 27, Raiders 17

I’m putting my money on the Chargers at -3.5 and I’m also favoring the under at 46.5. This game seems promising for L.A. in terms of both offense and defense, and unless Vegas can force some turnovers or pull off a few big plays, I doubt they’ll be able to keep pace.