NFL : Carolina Panthers vs San Francisco 49ers Odds & Prediction

Game Info: November 24, 2025 8:15PM EDT @ Levi’s Stadium

Carolina is going to San Francisco on a confidence wave after a series of really good games. Their excellent past against the 49ers and capability to perform well on the road create a very interesting meeting with a powerful San Francisco attack.

Betting Odds and Info

These are the latest odds as of writing:

Moneyline: Panthers 4.07 , 49ers 1.25

Spread: Panthers +7.5 , 49ers -7.5

Over/Under: 50

Team Recent Performance

Carolina Panthers

During their last five games, the team displayed inconsistency. They managed to win tight road games against Atlanta, Green Bay, and New York Jets, nevertheless, they lost at home to New Orleans and Buffalo. They are able to bounce back in close games, but consistency is the key for them to be able to face strong opponents.

San Francisco 49ers

The team’s last five matches have been a roller coaster ride performance-wise as they had two remarkable wins away from home at Arizona (41-22) and New York (34-24) along with losing encounters in Los Angeles (26-42) and Houston (15-26). The triumph over the Falcons (20-10) at their own ground, though, tells of their capabilities; nonetheless, the inconsistency issue remains.

Team Head-to-Head Matchup

The Panthers (1-2) are in for a tough test as they go up against the 49ers (2-1), who have the upper hand in the offense department with their scoring and total yardage stats which read 30.3 points and 334 total yards per game while the Panthers have 17 points and 275 yards. In addition to this, San Francisco also excels in the ground game (145.3 vs. 103.3) and has a very slight advantage when it comes to turnovers. Even though the two teams have approximately the same passing production, the Panthers will have to rely on their discipline and efficiency to match the 49ers’ well-distributed attack.

Betting Trends

Carolina Panthers

Carolina is on the upswing lately, winning 5 out of their last 7 games with both the straight-up and against-point spread record of 5-2. The Panthers have had a clear upper hand so far in their meetings with the 49ers, winning 10 times and losing 5 times along with a positive spread of 14-4, which includes 9-2 for the away games. When it comes to NFC rivals, they have a record of 4-1 SU, yet the totals are not consistent—OVER tends to be the outcome frequently in games against the NFC West teams, while November matches don’t usually go past the UNDER trend.

San Francisco 49ers

The San Francisco 49ers have had a tough time with the spread, having a record of 7-13 ATS in the last games, and 1-5 for home games against the Carolina Panthers, still, the OVER has come through often in their games—six times in eight and fifteen times in twenty games played against the Panthers. Straight-up, the 49ers are still a powerhouse, as they win almost all their games against the NFC South teams and Week 12 matchups.

SPORTBOOK.AG’s Prediction

The 49ers will win and cover the spread with the total going over 50.

Check out our suggested sportbook listed if you’re seeking for a good site to wager on this matchup.