NFL : Buffalo Bills vs Houston Texans Odds & Prediction

Game Info: November 20, 2025 8:15PM EST @ NRG Stadium

The explosive offense of Buffalo travels to Houston, where the Texans’ tight defense has mostly kept the rival teams under their scoring rates the whole year. This match is going to be a test of the ability of Buffalo to score against the talent of Houston to control the score.

Betting Odds and Info

These are the latest odds as of writing:

Moneyline: Bills 1.38 , Texans 3.16

Spread: Bills -5.5 , Texans +5.5

Over/Under: 43.5

Team Recent Performance

Buffalo Bills

Buffalo has just demonstrated their scoring ability and, at the same time, their erratic behavior. Their offensive power is confirmed by considerable victories over Tampa Bay, Kansas City, and Carolina, however, defeats to Miami and Atlanta point to their difficulties competing with strong teams. In a nutshell, they can deliver stunning performances, nevertheless, still, they are in the quest for consistency.

Houston Texans

The last five matches of Houston have marked a triumphant showcase of their resilience with a blend of low-scoring and high-scoring games. Their victories over Tennessee, Jacksonville, and San Francisco stand out, yet losses by a hair’s breadth to Denver and Seattle point to their variability. In all, it has been a tightly contested season during which the team has displayed both their skills and their unpredictability.

Team Head-to-Head Matchup

The Bills step into this game with greater offensive power, boasting the highest points per game and significantly greater total yardage than the Texans. Houston’s completion percentage has been relatively high but the output has not improved because of turnovers and a lack of scoring which continue to impede the team. In general, Buffalo’s efficiency and balance make them statistically superior by a large margin.

Betting Trends

Buffalo Bills

Overall, Buffalo has been dependable, particularly in November, but has always had a hard time with Houston. The Bills are leaning much more towards the UNDER—especially when playing away in this match-up—and although their record for road ATS is somewhat mixed, they have been better against the AFC South teams.

Houston Texans

The Houston team has a very strong UNDER trend coming with them; they managed to win it in eight out of their last eleven games and were not very high scorers in the matches against Buffalo, particularly not during the games played at home. The Texans have won five out of their last seven games and have been performing quite well against AFC teams, but they have had a hard time with the AFC East and have not been very reliable ATS in November and during Week 12.

SPORTBOOK.AG’s Prediction

The Bills will win and cover the spread with the total staying under 43.5.

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