NFL : Atlanta Falcons vs San Francisco 49ers Odds & Prediction

Game Info: October 19, 2025 8:20PM EDT @ Levi’s Stadium

The Atlanta Falcons and San Francisco 49ers are poised to meet in this game with a combination of good and bad results, exhibiting at times their strength but at other times their weakness. The Falcons, for instance, have gone ahead and secured some major wins after suffering their share of losses, whereas the 49ers have not been able to keep the score at a high level even though at times their offense has been very powerful.

Betting Odds and Info

These are the latest odds as of writing:

Moneyline: Falcons 2.10 , 49ers 1.78

Spread: Falcons +1 , 49ers -1

Over/Under: 47

Team Recent Performance

Atlanta Falcons

In their most recent five games, they have a record of 3-2, having recovered after suffering a severe defeat at Carolina with the score of 0-30. Among their victories were Buffalo and Washington, while Tampa Bay defeated them by a narrow margin. Their scoring was not steady so three of their last five games went under the total which indicates that the team is a good candidate for a comeback but still has the problem of being inconsistent offensively.

San Francisco 49ers

They have recorded a 3-2, indicating that part of them is strong and part is weak at the same time. They managed to win very closely on the road against Los Angeles but lost to Tampa Bay. At home, they saved themselves against Arizona by a hair’s-breadth and succumbed to Jacksonville. The team has been a scoring enigma, which is illustrated by their inconsistent performance against the spread and numerous games with high totals, signifying that the team has the power to score but sometimes this power is not stable.

Team Head-to-Head Matchup

The Atlanta Falcons (2-1) and the San Francisco 49ers (1-2) are going to play a totally different kind of game. Atlanta slightly overtakes the scoring department with 23.33 points per game, whereas San Francisco is on top of passing with 241.33 yards and a 69.7% success rate, making it hard for Atlanta to come up with an answer to the 49ers’ total yardage (352 vs. 284.67). Besides, despite San Francisco’s ability to gain more yards in the air, the Falcons are stronger on the ground with 106.33 rushing yards per game. The issue of turnovers will play a big part in the outcome of the game since Atlanta commits 0.67 turnovers while San Francisco 2.

Betting Trends

Atlanta Falcons

They have managed to cover the spread in three out of their last five games but they are only one win and one loss when it comes to road games. Their scoring has been nothing spectacular, with the point totals going OVER in only one of their last five games and one of their last three home games, which suggests they still have low-scoring games in general.

San Francisco 49ers

In their recent five matches the San Francisco 49ers’ performance has been rather mixed as far as the spread is concerned- they have won only 2 times out of 5, however, their road performances were quite impressive as they managed to cover the spread 4 out of 4 times. The OVER is the result of the total in three of their last five games, although at home just one of the last two games has gone over the total.

SPORTBOOK.AG’s Prediction

The San Francisco 49ers will win and cover the spread with the total staying under 47.

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