MLB: San Diego Padres at San Francisco Giants Odds & Prediction

Game Info: Monday, August 11, 2025, 9:45 PM ET, Oracle Park, San Francisco, CA

Betting Odds:

Moneyline: Giants – 141 | Pares +120

Spread (Run Line): Giants -1.5 (+144) | Padres +1.5 (-171)

Over/Under: 7.5 (-110)

Implied Win Probability: Giants 58.5%, Padres 45.5%

Padres Betting Preview

The San Diego Padres are entering this game with an impressive 66-52 record, riding high with 7 victories in their last 10 games. Offensively, they’re led by Manny Machado (.297 AVG, 20 HR, 72 RBI) and Fernando Tatis Jr. (.262 AVG, 17 HR), while Luis Arraez (.295 AVG) contributes consistent contact hitting.

Yu Darvish (1-3, 6.51 ERA) is set to pitch, but he’s been struggling to find his rhythm this season, averaging just 5.1 innings per game. His issues with command and brief appearances could pose a challenge against a Giants lineup that’s great at working the count.

Even though they’re seen as underdogs, the Padres have managed to win 50.9% of their games in that role this season. Their away record (28-32) is pretty average, but they’ve outperformed their opponents in 49 games, boasting a 49-14 record in those matchups.

Giants Betting Preview

The Giants are sitting at an even 59-59 and are looking to gain some ground in the NL West. Logan Webb (10-8, 3.24 ERA) is ready to take the mound, coming off a stellar performance where he fanned 10 batters. He’s been really consistent at home, boasting a career ERA of 2.70 at Oracle Park.

San Francisco’s offense is led by Rafael Devers (22 HR, 80 RBI) and Heliot Ramos (.274 AVG), yet the team ranks 25th in batting average (.233) and 28th in slugging percentage (.375). Their success in close games relies significantly on Webb’s performance and their capacity to stop runs.

The Giants hold a 38-20 record in games where they’ve successfully kept home runs at bay, which is a key stat when going up against a Padres team that ranks among the lowest in home runs.

Matchup/League Facts

Season Series: Padres lead 4-2

Padres Run Differential: +50 (489 scored, 439 allowed)

Giants Run Differential: +9 (488 scored, 477 allowed)

Padres Road Record: 28-32

Giants Home Record: 29-28

Padres Batting Avg: .251 (9th in MLB)

Giants Batting Avg: .233 (25th in MLB)

This game showcases two teams aiming for the playoffs, each with their own unique strengths. The Padres come in with solid offensive play and good momentum, whereas the Giants depend on their pitching skills and the benefits of playing at home.

Padres at Giants Prediction

Get ready for an intense match at Oracle Park. While Logan Webb gives the Giants a pitching edge, the Padres’ recent form and more powerful lineup could change the game. If Darvish can limit the damage early, San Diego’s batters might just outdo the Giants in a thrilling finish.

Sportbook.AG Final Prediction: Padres 5, Giants 4 Pick: Padres +120 ML Total: Over 7.5 runs

This matchup between the Padres and Giants could really set the vibe for the series and might be a key moment in the NL West playoff chase.