MLB: Milwaukee Brewers at Chicago Cubs Odds and Prediction

Game Info: Milwaukee Brewers (79-48) at Chicago Cubs (73-54), Thursday, August 21, 2025, 2:20 p.m. ET, Wrigley Field, Chicago, IL

Betting Odds

Moneyline: Cubs -142 | Brewers +120

Run Line: Cubs -1.5 (+155) | Brewers +1.5 (-188)

Total Runs (O/U): 7 (Over -106 | Under -114)

Win Probability: Cubs 51% | Brewers 49%

Brewers Betting Preview

Milwaukee is coming into this Brewers-Cubs game with the top record in the National League and a strong nine-game lead in their division. Quinn Priester is set to pitch, and although his 11–2 record with a 3.48 ERA is impressive, it’s worth mentioning that Milwaukee’s run line performance during his starts has been hit or miss, only covering in two of his last five games.

Leading the charge on offense, Christian Yelich has hit 26 home runs and racked up 87 RBIs. Sal Frelick (.299 AVG, .364 OBP) and Brice Turang (.279 AVG, .759 OPS) have been reliable at getting on base, and Milwaukee’s lineup has been scoring an average of 7 runs per game in their last 10 outings.

Cubs Betting Preview

The Cubs are clinging to their playoff hopes as they face off against the Brewers, looking for a crucial win. Shota Imanaga (8–5, 3.06 ERA) has been performing well, but the team’s results during his games have been inconsistent. This season, Chicago has a record of 15–22 when they’re the moneyline underdog, and they’ve had an even tougher time with a 13–31 record when the odds are -100 or worse.

Pete Crow-Armstrong and Seiya Suzuki have hit a total of 54 home runs together, and Nico Hoerner, with a .291 batting average, is still the most reliable hitter on the team. Recently, Chicago’s offense has struggled to maintain consistency, averaging just 4.2 runs in their last 10 games, which is worrying as they get ready to face Milwaukee’s excellent pitching staff, currently ranked 2nd in MLB with a 3.56 ERA.

Matchup/League Facts

Milwaukee leads the NL with a run differential of +163 and is currently in second place for team ERA at 3.56.

The Cubs have a 51% win rate when they’re favored, but they struggle quite a bit as underdogs, especially against top-notch pitchers.

The Brewers have taken 7 out of their last 10 games, but they’ve only hit the over in 4 of those contests.

The Cubs are 4–6 against the spread (ATS) in their last 10 games, and they’ve managed to go over in 3 of those matchups.

Brewers at Cubs Prediction

This game between the Brewers and Cubs is shaping up to be a clash of momentum versus home-field strength. Milwaukee’s offense has been explosive, averaging 7.5 runs per game over their last 10 games, and Quinn Priester has been delivering strong performances. On the other hand, Chicago enters as the favorite, thanks to a strong home record and a much-needed boost in their batting lineup. With the Cubs set at -142, the oddsmakers appear to lean towards a win at Wrigley.

Sportbook.AG Prediction: Cubs 5, Brewers 3 Pick: Cubs -142  Lean: Under 7

If you’re thinking about betting on the Brewers vs. Cubs game, keep in mind Chicago’s consistent performance and their edge in pitching. Pay attention to the live totals, especially if the wind shifts at Wrigley, it could impact the over/under line as the game goes on.