MLB: Chicago Cubs at Toronto Blue Jays Odds & Prediction

Game Info: Wednesday, August 13, 2025, 7:07 p.m. ET, Rogers Centre, Toronto, Ontario

This interleague clash between the Chicago Cubs and Toronto Blue Jays is not just another game in the middle of the week, it’s a potential playoff preview. With both teams over .500 and fighting for their positions, you can count on a lot of energy right from the first pitch.

Betting Odds & Lines

Moneyline: Blue Jays -132 | Cubs +112

Run Line: Blue Jays -1.5 (+153 | Cubs +1.5 (-186)

Total Runs (O/U): 8.5 (Over -114 / Under -106)

Toronto kicks things off as a slight favorite, but it’s tough to ignore the allure of the Cubs as a road underdog, especially considering how well their pitchers have been performing lately.

Cubs Betting Preview

The Cubs are stepping into this game with a 67–51 record and a little bit of an edge. Rookie sensation Cade Horton is taking the mound, showing off a 3.18 ERA and a scoreless streak that goes back 23.1 innings. Horton’s precision and calmness have made him one of the most reliable young pitchers in the National League.

Offensively, Chicago continues to mash:

Pete Crow-Armstrong has hit 27 home runs and brought in 78 RBIs.

Seiya Suzuki continues to be a reliable player with 74 RBIs and a batting average of .278.

Nico Hoerner is quietly maintaining a .301 batting average and is doing a great job setting things up for the power hitters.

The Cubs have gone over the total in 6 out of their last 9 games, and their bullpen has been solid with an ERA below 3.50 in the last two weeks. This game could be a big moment for Chicago as they aim to show they can compete with AL contenders.

Blue Jays Betting Preview

Toronto’s sitting at 70–50 and has been super solid at home with a 39–19 record. Kevin Gausman is on the mound, fresh off an amazing seven-inning outing against Colorado. Despite his season ERA being 3.85, he’s been totally on fire this August.

The Blue Jays’ lineup is stacked:

Vladimir Guerrero Jr. is hitting .296 with 19 home runs and 64 RBIs.

Bo Bichette is crushing it with a .298 batting average and 78 RBIs.

Ernie Clement is on a roll, batting .378 with 3 homers in his last ten games.

Toronto is leading the league with a team batting average of .269 and ranks in the top 10 for slugging. However, their bullpen has been somewhat inconsistent lately, posting a 5.70 ERA in August. This could be a crucial factor in this matchup.

Matchup & League Trends

Blue Jays are 6–4 ATS in their last 10 matchups

Cubs are 4–6 ATS in their last 10 matchups

Toronto has won the last head-to-head meeting 5–1

Cubs are 22–14 vs. AL teams this season

Blue Jays are 30–21 vs. NL opponents

This game between the Cubs and Blue Jays features two teams known for their high-scoring abilities and two pitchers who are heading in opposite directions. Toronto has been playing great at home and knows how to work the count, which gives them the upper hand. However, with Horton pitching effectively, the outcome is still up in the air.

Cubs at Blue Jays Prediction

This game is really a battle between value and consistency. The Cubs have a pitcher who’s absolutely on fire, but the Blue Jays have a more powerful lineup and the advantage of being at home. Brace yourself for a nail-biter as the tension builds in the last innings.

Sportbook.AG Final Score Prediction: Blue Jays 5, Cubs 4 Best Bet: Over 8.5 Runs Lean: Blue Jays Moneyline (-132)

If you’re betting on the Cubs vs. Blue Jays game, make sure to watch the live totals and the bullpen matchups. This game could shift in the last moments and that’s when savvy bettors can cash in.