NFL : Philadelphia Eagles vs Buffalo Bills Odds & Prediction

Game Info: December 28, 2025 4:25PM EST @ Highmark Stadium

Philadelphia goes to Highmark Stadium to face a strong Buffalo team that has an unbeaten record against the Bills in the matchup. The Eagles count on a balanced attack while the Buffalo offense has been scoring a lot at home which makes their game a clash of styles.

Betting Odds and Info

These are the latest odds as of writing:

Moneyline: Eagles 2.11 , Bills 1.76

Spread: Eagles +1 , Bills -1

Over/Under: 44

Team Recent Performance

Philadelphia Eagles

The Eagles have been successful in three out of their last five games, with particularly powerful victories against Washington and Las Vegas being among them. Even though there have been some games with the total score UNDER, very close defeats to the Chargers, Bears, and Cowboys prove that they still fight for victory.

Buffalo Bills

The Bills are on a great run, winning four out of five games and most of the time scoring more than 26 points, and the OVER has been successful in three of their last four games. The Bills’ only loss in recent weeks was the one against Houston, but the team is still carrying the positive energy into the next game.

Team Head-to-Head Matchup

The Philadelphia Eagles are going to the direct matchup with undoubtedly the best position, being 3–0 not only straight up but also against the spread, while the Buffalo Bills are still winless in both counts, at 0–3. The Eagles score more than 30 points on average per game driven by their good running game, while Buffalo presents a more productive passing game with total yardage but has trouble being efficient and scoring, which leads to a scoring average of just 22.33 points. Despite having the same amount of turnovers, Philadelphia’s balance and execution have determined the winner.

Betting Trends

Philadelphia Eagles

In their previous 20 encounters, the Eagles have a record of 15–5 when it comes to outright win and loss decisions and they have been successful in 6 out of their last 9 games according to the point spread, while the total has been UNDER in six of their last seven games. They have also been superior to the like of Buffalo and AFC opponents, winning 5 out of 6 games against the Bills and 11 out of 13 games in the conference.

Buffalo Bills

The Bills have won five out of their last six games and have a record of 16–1 at home. In December and when playing against NFC opponents, the OVER went very high often. On the other hand, they have not been able to cover the spread even though they had a good performance during Sunday home games.

SPORTBOOK.AG’s Prediction

The Bills will win but the Eagles will cover the spread with the total going over 44.

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