NFL: Indianapolis Colts at Los Angeles Rams Odds & Prediction

Game Info: Sunday | September 28, 2025 | 4:05 PM ET |  SoFi Stadium, Inglewood, CA

Betting Odds

Most sportsbooks have the Rams favored by 3.5 points, and the total is at 49.5. The moneyline shows the Rams at -185 and the Colts at +154. Interestingly, this line started at Rams -4.5 with a total of 47, indicating some early movement towards Indy and the over, probably influenced by sharp betting and the public’s enthusiasm for the Colts’ offensive boost.

Colts Betting Preview

Honestly, who thought Daniel Jones and the Colts would be at the top of the AFC South after only three weeks? Yet here we are. Jones has been incredible, throwing three touchdown passes and rushing for three more, all while protecting the ball with zero interceptions. Shane Steichen’s offense is on a roll, averaging 34.3 points per game, the second-highest in the NFL.

Jonathan Taylor seems to be back in form, and the offensive line is providing him the space he needs. On the defensive side, Indy is taking advantage of opportunities, forcing five turnovers and placing in the top 10 for total yards allowed. The Colts have managed to cover the spread in all three games and have gone over the total points each time. This team isn’t just stacking up victories, they’re also making some money.

Rams Betting Preview

The Rams just faced a hard-fought 33-26 defeat against the Eagles, with two blocked field goals in the final minutes turning the tide. But you know what? Sean McVay’s squad has shown resilience. Matthew Stafford, now 37, is delivering solid performances with five touchdowns over three games, and Kyren Williams is emerging as a genuine RB1 candidate.

On the defensive side, the Rams are fifth in terms of yards allowed, but they’ve struggled a bit in the red zone, allowing an average of 20.3 points per game. They’ve managed to cover the spread in all three of their games and are 2-1 against the spread at home since last season. This matchup between the Colts and Rams will really test their capability to deal with a high-octane offense.

Matchup/League Facts

Colts are 3-0 ATS and 3-0 to the over.

The Rams are 6th in rushing efficiency, while the Colts sit at 27th in rush defense.

Both teams have played the Titans recently: Rams won 33-19, Colts won 41-20.

Daniel Jones has yet to commit a turnover this season.

Colts at Rams Prediction

This game between the Colts and Rams seems set for a scoring frenzy. Both squads have significant weaknesses in their run defense, and neither has been able to reliably stop their opponents from scoring. I’m leaning towards the Colts +3.5 for this matchup. They’ve been underestimated all season and keep exceeding expectations. However, the Rams are tough to beat at home, so I wouldn’t be surprised if this one goes down to the wire.

Sportbook.AG Final Prediction: Score: Rams 30, Colts 28 Best Bet: Colts +3.5 Lean: Over 49.5