MLB: San Diego Padres at Los Angeles Dodgers Odds & Prediction

Game Info: Friday, August 15, 2025, 9:10 PM ET, Dodger Stadium, Los Angeles, CA

The Padres and Dodgers are gearing up for an important weekend series, showcasing two strong teams from the NL West. With San Diego gaining momentum and Los Angeles facing challenges, this matchup could be a key turning point in the division race.

Betting Odds

Moneyline: Dodgers -138 | Padres +118

Run Line: Dodgers -1.5 (+142) | Padres +1.5 (-172)

Total Runs (O/U): 8.5 (Over -115, Under -105)

Padres Betting Preview

San Diego is rolling into this game with a ton of momentum, having won five in a row and now leading the Dodgers in the NL West. The Padres have an overall record of 69-52 and are 31-32 when playing away from home. Michael King (4-2, 2.81 ERA) is ready to start, making his second appearance since returning from the IL. This season, he has a 3.63 ERA in three road starts.

On offense, the Padres are fueled by Manny Machado (.296 AVG, 20 HR, 72 RBI) and Fernando Tatis Jr. (.266 AVG, 17 HR). Newcomer Ramon Laureano is on a roll, batting .333 with a 1.000 OPS over his last 15 games. San Diego’s bullpen is at the top of the MLB in holds and boasts a solid 72.7% save conversion rate.

Dodgers Betting Preview

The Dodgers (68-53) are on a five-game losing streak and currently sit half a game behind the Padres. Clayton Kershaw (6-2, 3.14 ERA) is ready to help change their luck. He’s 9-5 in his starts this year and has a career WHIP of 0.995.

Despite the recent setback, L.A. remains a challenging environment. Shohei Ohtani is on fire, currently riding a 12-game hitting streak with an impressive .432 average, 16 hits, 5 home runs, 6 RBIs, and 14 runs scored in his last 10 games. Will Smith, boasting a .312 batting average and 15 home runs, has been a force at home, hitting .338 and achieving a 1.019 OPS at Dodger Stadium. The Dodgers hold a strong record of 38-24 at home and 19-7 in division games, both of which are the best in MLB.

Matchup/League Facts

Head-to-Head: Dodgers lead season series 5-2

Padres ATS: 66-55 | Dodgers ATS: 52-69

Over Trends: The Padres have hit the over in 6 of their last 10 games

Dodgers as Favorites: 58.1% win rate when favored

Padres as Underdogs: 52.7% win rate when listed +118 or worse

This game between the Padres and Dodgers highlights two teams on different paths. San Diego’s recent acquisitions and solid pitching have given them a boost as the season winds down, while the Dodgers are searching for answers amid an unexpected slump.

Padres at Dodgers Prediction

The Padres are showing off their confidence, and with Michael King returning, their rotation seems much more reliable. However, the Dodgers boast a lineup that’s too powerful to stay quiet for an extended period, particularly when they’re playing at home. Kershaw’s experience combined with the urgency to end a losing streak gives L.A. an advantage in this matchup.

Sportbook.AG Final Prediction: Dodgers 6, Padres 4 Best Bet: Over 8.5 Runs Lean: Dodgers -138 ML

This game between the Padres and Dodgers isn’t just any regular-season matchup, it’s a battle for supremacy in the NL West. Brace yourself for thrills, suspense, and an atmosphere that resembles the playoffs at Chavez Ravine.